Preheat the oven to 180°C/350°F/Gas Mark 4.

Bring a large pot of salted water to a boil. Add elbow macaroni and cook until al dente, about 8-10 minutes. Drain and set aside.

In a medium saucepan, melt butter over medium heat. Add all-purpose flour and whisk until smooth. Cook for 2-3 minutes, stirring constantly.

Gradually whisk in whole milk and heavy cream. Cook for 5-7 minutes, whisking occasionally, until the mixture is thickened and bubbly.

Remove the saucepan from heat and add shredded cheddar cheese, shredded mozzarella, grated Parmesan cheese, Dijon mustard, salt, and black pepper. Stir until the cheese is melted and the sauce is smooth.

Add the cooked macaroni to the saucepan and stir until the macaroni is evenly coated with the cheese sauce. Transfer the mac and cheese to a baking dish. Sprinkle panko breadcrumbs over the top of the mac and cheese.

Bake the mac and cheese for 20-25 minutes, until the breadcrumbs are golden brown and the cheese is bubbly. Let the mac and cheese cool for 5-10 minutes before serving.